Structural analysis of SALL4 zinc-finger domain reveals a link between AT-rich DNA binding and Okihiro syndrome
J. A. Watson, R. Pantier, U. Jayachandran, K. Chhatbar, B. Alexander-Howden, V. Kruusvee, M. Prendecki, A. P. Bird, A. G. Cook
This study presents the crystal structure of SALL4 zinc fingers bound to AT-rich DNA, showing flexible recognition and links to Okihiro syndrome mutations.
bioRxiv · Jun 14, 2022Biochemistry