Delineating the heterogeneity of matrix-directed differentiation towards soft and stiff tissue lineages via single-cell profiling
S. Brielle, D. Bavli, A. Motzik, Y. Kan-Tor, B. Avni, O. Ram, A. Buxboim
The paper uses single-cell profiling to identify MSC subpopulations with distinct mechanosensitivities and shows that TPM1 expression determines adipogenic or osteogenic fates based on matrix stiffness.
bioRxiv · Nov 23, 2020Cell Biology