The Importance of Reverse Translation for Preclinical Off-Target Mitigation: Quantification and Mitigation of Biases in the FDA Adverse Event Reporting System
M. Maciejewski, E. Lounkine, S. Whitebread, P. Farmer, B. DuMouchel, B. K. Shoichet, L. Urban
This paper quantifies and mitigates biases in the FDA Adverse Event Reporting System (FAERS) by mapping drug identifiers to chemical structures, revealing underlying molecular mechanisms of adverse drug reactions.
bioRxiv · Aug 14, 2016Pharmacology & Toxicology