SARS-CoV-2 immune complex triggers human monocyte necroptosis
L. Santos, K. H. Antunes, G. Cassao, J. I. Goncalves, B. L. Abbadi, C. V. Bizarro, L. A. Basso, P. Machado, A. P. D. d. Souza, B. Porto
This study shows SARS-CoV-2 and its immune complexes induce monocyte necroptosis via RIPK3 and MLKL, with Syk kinase involvement, and links elevated LDH to COVID-19 pathogenesis.
bioRxiv · Oct 13, 2022Immunology