B. Westereng

A technical pipeline for screening microbial communities as a function of substrate specificity through single cell fluorescent imaging

The paper develops a technical pipeline using fluorescent imaging to screen microbial communities for substrate specificity in glycan metabolism.

Human gut Faecalibacterium prausnitzii deploy a highly efficient conserved system to cross-feed on β-mannan-derived oligosaccharides

This study identifies a conserved system in Faecalibacterium prausnitzii that enables efficient cross-feeding on β-mannan-derived oligosaccharides, enhancing butyrate production in the human gut.

Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut.

This study shows that a tailored acetylated galactoglucomannan fibre selectively activates butyrate-producing gut bacteria and triggers secondary metabolic shifts in neighboring microbial populations in pigs.

Synthesis of Glycoconjugates Utilizing the Regioselectivity of a Lytic Polysaccharide Monooxygenase

This study uses lytic polysaccharide monooxygenases to selectively oxidize non-reducing ends of oligosaccharides, enabling the synthesis of oxime-based glycoconjugates and demonstrating their potential biodegradability.

A pair of esterases from a commensal gut bacterium remove acetylations from all positions on complex β-mannans

This paper identifies two esterases from a gut bacterium that cooperatively deacetylate complex β-mannans, revealing their structural and functional mechanisms.