Bridging Stem Cell Models and Medicine: Integrated 3D Human Cerebral Organoids and Pediatric Serum Reveal Mechanisms and Biomarkers of Anesthetic-Induced Neurotoxicity
Tarun Pant, Congshan Jiang, Yasheng Yan, Bailey Schultz, Daniel Laws, Sarah Logan, Amina Bedrat, Matea Juric, Richard J. Berens, Susan P Taylor, Amy Henry, Zeljko J. Bosnjak, Xiaowen Bai
This study uses 3D human cerebral organoids and pediatric serum to identify molecular signatures of anesthetic-induced neurotoxicity, revealing shared dysregulated RNAs linked to neuronal injury and neurodevelopmental disruption.
bioRxiv · Apr 23, 2025 · PreprintNeuroscience