Simulating CD8 T Cell Exhaustion: A Comprehensive Approach
Andrea J. Manrique-Rincón, Ben Foster, Stuart D. Horswell, David A. Goulding, David J. Adams, Anneliese O. Speak
The paper develops an in vitro model of CD8 T cell exhaustion and identifies a gene signature that defines the exhausted state in both in vitro and in vivo settings, with validation in human tumor samples.
iScience · Jun 12, 2025Peer-reviewedImmunology