Deciphering sepsis molecular subtypes using large-scale data to identify subtype-specific drug repurposing
Leslie Arthur Smith, Beulah Augustin, Vinitha Jacob, Lauren Page Black, Andrew H. Bertrand, Charlotte Hopson, Emilio B. Cagmat, Susmita Datta, Srinivasa T. Reddy, Faheem W. Guirgis, Kiley S. Graim
This paper identifies four molecular subtypes of sepsis using transcriptomic data and proposes subtype-specific drug repurposing opportunities, including potential therapies for high mortality subtypes.
bioRxiv · Sep 28, 2026 · PreprintBioinformatics