The small molecule inhibitor SU056-mediated targeting of YB1 inhibits the Rb pathway in triple-negative breast cancer tumors
Wei Wang, Yeaji Kim, Xiaotong Zhao, Kristen Weber Bonk, Ruth A. Keri, Bin Su, Khalid Sossey‐Alaoui
This study shows that SU056, a YB1 inhibitor, suppresses TNBC growth and metastasis by targeting the Rb pathway, with enhanced efficacy when combined with CDK4/6 inhibition.
bioRxiv · Sep 10, 2026 · PreprintCancer Biology