Bing He

Towards building a World Model to simulate perturbation-induced cellular dynamics by AlphaCell

AlphaCell simulates perturbation-induced cellular dynamics by addressing limitations in current models through three innovations: latent manifold rectification, biological reality reconstruction, and universal state transition.

A Generative Foundation Model for Antibody Design

IgGM is a generative model for antibody design that produces high-affinity antibodies through tasks like structure prediction and affinity maturation, validated on multiple antigens.

Fast and accurate modeling of TCR-peptide-MHC complexes using tFold-TCR

The paper introduces tFold-TCR, a model for predicting TCR-pMHC structures, achieving higher accuracy and speed than existing methods and creating a large database of these structures.

Fast and accurate modeling and design of antibody-antigen complex using tFold

This paper introduces tFold-Ab and tFold-Ag for fast and accurate prediction of antibody and antibody-antigen complex structures, showing improved speed and performance over AlphaFold-Multimer.

DNAGPT: A Generalized Pre-trained Tool for Multiple DNA Sequence Analysis Tasks

DNAGPT pre-trains a modified generative pre-trained transformer (GPT) architecture on over 200 billion mammalian base pairs to jointly process sequence and numerical data across diverse DNA analysis tasks.

Construction of the third generation Zea mays haplotype map

The paper constructs the third generation Zea mays haplotype map using whole genome sequencing data from 1,218 maize lines, identifying 83 million variant sites.