Author

Brady James

Brigham and Women's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Approach:deep learning· 1

Frequent Co-Authors

Damien VasseuriD· 2 shared Gunsagar Singh GulatiiD· 2 shared Hunter SavignanoiD· 2 shared Ji-Heui SeoiD· 2 shared Karl SemaaniD· 2 shared Matthew L. FreedmaniD· 2 shared Rashad NawfaliD· 2 shared Toni K. ChoueiriiD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Damien VasseurORCID

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Author profile →

2 papers

Recent·Most cited

Transcription Factor Subtype Governs Response and Resistance to DLL3-Directed T-Cell Engagement in Small Cell Lung Cancer

Damien Vasseur, Shin Saito, Gunsagar Singh Gulati, Garyoung Gary Lee, Yasmin Nabil Laimon, Berkay Şímșek, Maddie Lerner, Hyeonseo Cho, Yixiang Li, Tianchu Wang, Ji-Heui Seo, Hunter Savignano, Brady James, Ze Zhang, Karl Semaan, , Matthew G. Oser

This study investigates how transcription factor subtypes in small cell lung cancer influence response and resistance to DLL3-targeted therapy, revealing subtype-specific mechanisms of resistance.

bioRxiv · Apr 8, 2026 · PreprintCancer Biology

Integrated inference of cancer gene expression from cell-free plasma chromatin

Gunsagar Singh Gulati, Damien Vasseur, Rashad Nawfal, Shahabeddin Sotudian, Karl Semaan, Marc Eid, Ji-Heui Seo, Noa Phillips, John Canniff, Hunter Savignano, Surya B. Chhetri, Zhenjie Jin, Yukun Ou, Mohamed Amine Bani, Gwo‐Shu Mary Lee, , Matthew L. Freedman

APEX infers cancer gene expression from plasma cfChIP-seq data, outperforming existing methods and enabling subtype classification and biomarker identification.

bioRxiv · Feb 19, 2026 · PreprintGenomics