Author

Bree Heestand

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Shawn Cameron AhmediD· 4 shared Matt SimoniD· 3 shared Maya SpichaliD· 3 shared Stephen Frenk· 3 shared Katherine Kretovich BillmyreiD· 2 shared Ahna R. SkopiD· 1 shared Aisa Sakaguchi· 1 shared Alicia S. WellmaniD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersGenetics

Shawn Cameron AhmedORCID

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Author profile →

4 papers

Recent·Most cited

DAF-16/Foxo suppresses the transgenerational sterility of prg-1 piRNA mutants via a systemic small RNA pathway

Matt Simon, Maya Spichal, Bree Heestand, Stephen Frenk, Ashley Hedges, Malik Godwin, Alicia S. Wellman, Aisa Sakaguchi, Shawn Cameron Ahmed

bioRxiv · May 13, 2025 · PreprintGenetics

Piwi mutant germ cells transmit a form of heritable stress that promotes longevity

Bree Heestand, Ben McCarthy, Matt Simon, Evan H. Lister‐Shimauchi, Stephen Frenk, Shawn Cameron Ahmed

The paper shows that prg-1 mutant C. elegans germ cells transmit heritable stress that promotes longevity but reduces fertility, with effects observed in F1 progeny.

Aging Cell · Nov 9, 2024Peer-reviewedGenetics

A reproductive arrest program triggered by defects in Piwi and germ granules

Maya Spichal, Bree Heestand, Katherine Kretovich Billmyre, Stephen Frenk, Craig C. Mello, Shawn Cameron Ahmed

The paper shows that defects in Piwi and germ granules in C. elegans lead to reproductive arrest through altered germ granules, not transposon activation, causing sterility.

Nature Communications · Mar 3, 2021Peer-reviewedDevelopmental Biology

The conserved phosphatase GSP-2/PP1 promotes germline immortality via small RNA-mediated genome silencing during meiosis

Katherine Kretovich Billmyre, Anna-Lisa Doebley, Maya Spichal, Bree Heestand, Tony Bélicard, Aya Sato, Stéphane Flibotte, Matt Simon, Megan M. Gnazzo, Ahna R. Skop, Donald G. Moerman, Peter Mark Carlton, Peter Sarkies, Shawn Cameron Ahmed

This paper identifies a meiosis-specific function of the phosphatase GSP-2 in promoting germ cell immortality through small RNA-mediated genome silencing in C. elegans.

PLoS Genetics · Mar 28, 2019Peer-reviewedGenetics