Brr2p-mediated unwinding of U4/U6 is promoted by a mutually exclusive intra-molecular stem loop in U4 and involves destabilization of the 5' stem-loop of U4
Klaus H Nielsen, Brenden Johnson, Amartya Das, Jonathan P. Staley
The paper investigates how Brr2p unwinds U4/U6 base pairs in yeast by disrupting U4 secondary structures and shows that an intramolecular stem loop in U4 antagonizes U4/U6 reannealing.
RNA · Oct 26, 2026Peer-reviewedMolecular Biology