Acetylated PLIN2 coordinates the innate immune system and oxylipin synthesis on lipid droplets to propagate inflammation
Charles P. Najt, Mahima Devarajan, Alex Churchill, Evan Kerr, Lauren Boatner, Samuel D. Gerrard, Brian Fess, Candace R. Guerrero, LeeAnn Higgins, Stacy Gelhaus Wendell, Douglas G. Mashek
This study identifies acetylated PLIN2 as a critical mediator of inflammation by facilitating oxylipin synthesis on lipid droplets through interactions with inflammatory proteins.
bioRxiv · Oct 4, 2026 · PreprintImmunology