Massively parallel assessment of designed protein solution properties using mass spectrometry and peptide barcoding
David Feldman, Jeremiah Nelson Sims, Xinting Li, Richard S. Johnson, Stacey Gerben, David E. Kim, Christian Richardson, Brian Koepnick, Helen E. Eisenach, Derrick R. Hicks, Erin C. Yang, Basile I. M. Wicky, Lukas F. Milles, Asim K. Bera, Alex Kang, , David A. Baker
The paper develops a method to assess solution properties of designed proteins using mass spectrometry and peptide barcoding, enabling analysis of large protein libraries.
bioRxiv · Feb 24, 2025 · PreprintBiochemistry