Pathological Oxidation of PTPN12 Underlies ABL1 Phosphorylation in HLRCC
Yang Xu, Paul Taylor, Joshua Andrade, Beatrix Ueberheide, Brian Shuch, Peter M. Glazer, Ranjit S. Bindra, Michael F. Moran, Marston W. Linehan, Benjamin G. Neel
This study identifies ROS-induced oxidation of PTPN12 as the mechanism underlying ABL1 phosphorylation in HLRCC-associated PRCC.
bioRxiv · Apr 6, 2018 · PreprintCancer Biology