Author

Brian Yoon

Brown University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:proteomics· 1

Frequent Co-Authors

Sofia B. LizarragaiD· 3 shared Alexis Guevara· 2 shared Calvin S. LeungiD· 2 shared Colleen L. Krall· 2 shared Megha JhanjiiD· 2 shared Abbie M. Maguire· 1 shared Anna R Montazzoli· 1 shared Cayla WolfeiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersNeuroscience

Sofia B. LizarragaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cellular Morphology and Motility Defects are Conserved Phenotypes of Trisomy 21 Despite Heterogeneous Adhesion Mechanisms

Katelyn Rygel, K. Chambers, Brian Yoon, Manasi Agrawal, Samantha Bailey, Mitesh Patel, Cayla Wolfe, Anna R Montazzoli, Taylor Bumbledare, Paige Cassidy Malcom, Shelby Kelemen, Connor Neifert, Jordan A. Headen, Leah J. Kershner, Nikita Kirkise, Kristy Welshhans

This study shows that cellular morphology and motility defects are consistent in Down syndrome across different cell types, despite variable adhesion mechanism changes.

bioRxiv · Aug 29, 2026 · PreprintCell Biology

The intersection of inflammation and DNA damage as a novel axis underlying the pathogenesis of autism spectrum disorders

Megha Jhanji, Colleen L. Krall, Alexis Guevara, Brian Yoon, Mathew Sajish, Luigi Boccuto, Sofia B. Lizarraga

The paper investigates the molecular link between maternal inflammation and ASD by identifying a shared signature in human neurons exposed to IL-17A, suggesting DNA damage response defects contribute to ASD pathogenesis.

bioRxiv · Dec 11, 2024 · PreprintNeuroscience

Dynamic Regulation Of The Chromatin Environment By ASH1L Modulates Human Neuronal Structure And Function

Megha Jhanji, Joseph A. Ward, Calvin S. Leung, Colleen L. Krall, Foster D. Ritchie, Alexis Guevara, Kai Vestergaard, Brian Yoon, Krishna Amin, Stefano Berto, Judy Shih-Hwa Liu, Sofia B. Lizarraga

This study shows that ASH1L mutations disrupt chromatin regulation, leading to neuronal dysfunction and disease-related gene dysregulation, and identifies potential therapeutic strategies.

bioRxiv · Dec 2, 2024 · PreprintNeuroscience

Dysregulation of The Chromatin Environment Leads to Differential Alternative Splicing as A Mechanism Of Disease In a Human Model of Autism Spectrum Disorders

Calvin S. Leung, Shoshana J. Rosenzweig, Brian Yoon, Nicholas A. Marinelli, Ethan W. Hollingsworth, Abbie M. Maguire, Mara H. Cowen, Michael Schmidt, Jaime Imitola, Ece Dilber Gamsiz Uzun, Sofia B. Lizarraga

This study shows that VPA exposure alters chromatin environment, leading to changes in alternative splicing and gene expression in human cortical neurons, which may contribute to ASD pathogenesis.

Human Molecular Genetics · Jan 9, 2023Peer-reviewedNeuroscience