Creation of genomic chimeras via megabase scale genome expansion
Charles Sanfiorenzo, Raymond J Zhang, George Wythes, Megan Wang, Jianyi Huang, Jeongsoo Hur, Mikel Lipschitz, Jie Zhou, Russell Swift, Bryan Gerber, Kaihang Wang
This paper introduces ACE, a method to create genomic chimeras by integrating large genomic segments from donor cells into a recipient genome, demonstrating its ability to generate stable chimeric organisms across species barriers.
bioRxiv · Nov 6, 2026 · PreprintSynthetic Biology