Transcriptionally distinct atypical B cell populations contribute to insulin autoreactivity and show differential activation, isotype switching, and somatic hypermutation in early-stage type 1 diabetes individuals
Lindsay E Bass, Landon M. Clark, Bryan Han, Daniel J. Moore, Rachel H. Bonami
B cells from 24 early-stage type 1 diabetes individuals include four atypical clusters differing in switching and mutation; Cluster 10 had the highest insulin-binding antibody rate (5/16).
bioRxiv · Oct 2, 2026 · PreprintImmunology✦ In-depth digest