The one-week automated genome-wide optical pooled screen
Bryce Kirby, Matteo Di Bernardo, Iain M. Cheeseman, Paul C. Blainey
The paper introduces OttoSeq, an automated optical pooled screen platform that completes a genome-wide cell painting screen in eight days, analyzing over 5 million cells across 21,732 gene knockouts.
bioRxiv · Apr 19, 2026 · PreprintGenomics