Higher-order metabolic interactions among oral commensals gate pathobiont expansion through succinate-driven pH modulation
Dam Soh, Aadil Bhat, Lu Li, Metthew Smardz, Carol Parker, Erin Tiede, Brynn Nelson, Valerie Frerichs, Troy Wood, Laertis Ikonomou, Hung Ton-That, Patricia I Diaz
The paper identifies succinate as a mediator of interbacterial antagonism in the oral microbiome, showing how metabolic interactions among commensals regulate pathobiont expansion through pH modulation.
bioRxiv · Nov 5, 2026 · PreprintMicrobiology