In vitro ALPK1 kinase assay reveals new insights into ADP-heptose sensing pathway and kinase activity of disease-associated ALPK1 mutants
D. Garcia-Weber, A.-S. Dangeard, V. Teixeira, M. Hauke, A. Carreaux, C. Josenhans, C. Arrieumerlou
This study develops an in vitro kinase assay for ALPK1, revealing its phosphorylation of TIFA and altered activity in disease-associated mutants.
bioRxiv · Jan 4, 2023 · PreprintImmunology