Adenovirus-α-defensin complexes induce NLRP3-associated maturation of human phagocytes via TLR4 engagement
K. Eichholz, H. T. Tran, C. Cheneau, T. T. P. Tran, O. Paris, M. Pugniere, E. J. Kremer
This study shows HNP-1 binds HAdV capsids, redirects them to TLR4, triggering NLRP3 inflammasome and IL-1β release in human phagocytes without membrane disruption.
bioRxiv · Oct 26, 2021Immunology