Patient-derived Glioblastoma Stem cells transfer mitochondria through Tunneling Nanotubes in Tumor Organoids
G. PINTO, I. SAENZ DE SANTA MARIA, P. CHASTAGNER, E. Perthame, C. DELMAS, C. TOULAS, E. Moyal-Jonathan-Cohen, C. BROU, C. ZURZOLO
This study shows that glioblastoma stem-like cells form functional tunneling nanotubes (TNTs) that enable mitochondria transfer in 2D and 3D tumor organoids, suggesting a role in therapy resistance.
bioRxiv · Nov 21, 2020Cancer Biology