MicrobiologybioRxiv
Generation and evaluation of protease inhibitor-resistant SARS-CoV-2 strains
H. S. Bouzidi, J.-S. Driouich, R. Klitting…·F. Touret
The paper generates and evaluates SARS-CoV-2 mutants resistant to protease inhibitors nirmatrelvir and ensitrelvir, showing in vitro and in vivo resistance and linking M49L mutation prevalence to Xocova(R) use.
DOI 10.1016/j.antiviral.2024.105814