Author

R. Klitting

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:virus· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:whole-genome sequencing· 3 Research Focus:drug response / drug discovery· 2 Assay:metagenomics· 2 Approach:statistical model· 2

Frequent Co-Authors

X. de Lamballerie· 5 shared F. Touret· 3 shared G. Piorkowski· 3 shared A. Nougairede· 2 shared H. S. Bouzidi· 2 shared K. G. Andersen· 2 shared R. Amaral· 2 shared A. Fontaine· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersMicrobiology

X. de Lamballerie

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Genomic surveillance reveals that the dengue 2 virus lineage responsible for the 2023-2024 epidemic in the French Caribbean Islands is resistant to Mosnodenvir

H. S. Bouzidi, S. Sen, G. Piorkowski, L. Pezzi, N. Ayhan, A. Fontaine, T. Canivez, M. Geulen, R. Amaral, G. Grard, G. A. Durand, X. de Lamballerie, F. Touret, R. Klitting

The paper identifies a mutation in dengue virus genomes from the 2023-2024 French Caribbean epidemic that confers resistance to the anti-dengue compound mosnodenvir.

bioRxiv · Apr 10, 2024 · PreprintMicrobiology

Generation and evaluation of protease inhibitor-resistant SARS-CoV-2 strains

H. S. Bouzidi, J.-S. Driouich, R. Klitting, O. Bernadin, G. Piorkowski, R. Amaral, L. Fraisse, C. E. Mowbray, I. Scandale, F. Escudie, E. Chatelain, X. de Lamballerie, A. Nougairede, F. Touret

The paper generates and evaluates SARS-CoV-2 mutants resistant to protease inhibitors nirmatrelvir and ensitrelvir, showing in vitro and in vivo resistance and linking M49L mutation prevalence to Xocova(R) use.

bioRxiv · Nov 22, 2023Microbiology

Genomic and phenotypic analyses suggest moderate fitness differences among Zika virus lineages

G. Oliveira, C. B. F. Vogels, A. Zolfaghari, S. Saraf, R. Klitting, J. Weger-Lucarelli, C. O. Ontiveros, R. Agarwal, K. P. Leon, K. A. Tsetsarkin, E. Harris, G. D. Ebel, S. Wohl, N. D. Grubaugh, K. G. Andersen

The paper analyzes genomic and phenotypic data from Zika virus lineages to assess fitness differences during the 2015-2016 epidemic, finding moderate fitness changes but no significant virulence or transmission enhancement.

bioRxiv · Feb 1, 2022Evolutionary Biology

Predicting the evolution of Lassa Virus endemic area and population at risk over the next decades

R. Klitting, L. E. Kafetzopoulou, W. Thiery, G. Dudas, S. Gryseels, A. Kotamarthi, B. Vrancken, K. Gangavarapu, M. Momoh, J. Demby Sandy, A. Goba, F. Alhasan, D. S. Grant, R. F. Garry, A. R. Smither, , S. Dellicour

The paper predicts that Lassa virus endemic areas will expand beyond West Africa due to environmental changes, increasing the population at risk from 100 million to 700 million by 2070.

bioRxiv · Sep 22, 2021Microbiology

Live Zika virus chimeric vaccine candidate based on a yellow fever 17-D attenuated backbone

F. Touret, M. Gilles, R. Klitting, F. Aubry, X. de Lamballerie, A. Nougairede

This paper develops a chimeric Zika virus vaccine using a yellow fever 17-D backbone and shows it induces neutralizing antibodies and protects mice against ZIKV challenge.

bioRxiv · Jul 25, 2018Microbiology

Exploratory re-encoding of Yellow Fever Virus genome: new insights for the design of live-attenuated viruses

R. Klitting, T. Riziki, G. Moureau, G. Piorkowski, E. A. Gould, X. de Lamballerie

This study re-encodes the Yellow Fever Virus genome with synonymous mutations to create attenuated strains, finding that certain mutations reduce virulence without significantly affecting replication fitness.

bioRxiv · May 30, 2018Microbiology

Molecular determinants of Yellow Fever Virus pathogenicity in Syrian Golden Hamsters: one mutation away from virulence

R. Klitting, L. Roth, F. Rey, X. de Lamballerie

This study identifies key mutations in Yellow Fever Virus that enhance virulence in Syrian Golden Hamsters by analyzing their effects on disease symptoms and replication.

bioRxiv · Jan 31, 2018Microbiology