BiochemistrybioRxivPreprint
Molecular Mechanism of Hyperactivation Conferred by a Truncated TRPA1 Disease Mutant Suggests New Gating Insights
A. Bali, S. P. Schaefer, I. Trier…·C. E. Paulsen
This paper investigates the R919* TRPA1 mutant, showing it is functionally inactive alone but enhances agonist sensitivity when co-expressed with wild-type TRPA1, revealing a novel mechanism of channel hyperactivation.
DOI 10.1101/2022.01.05.475133