p.E152K-STIM1 mutation deregulates Ca2+ signaling contributing to chronic pancreatitis.
M. Burgos, R. Phillipe, F. Antigny, P. Buscaglia, E. Masson, S. Mukherjee, P. Dubar, C. Le Marechal, F. Campeotto, N. Lebonvallet, M. Frieden, J. Llopis, B. Domingo, P. B. Stathopulos, M. Ikura, , O. Mignen
The paper identifies a p.E152K-STIM1 mutation that disrupts Ca2+ signaling in pancreatic acinar cells, leading to trypsin activation and cell death in pancreatitis patients.
bioRxiv · Jan 22, 2020Cell Biology