S. Mukherjee

SMAS: Structural MRI-Based AD Score using Bayesian VAE

This paper introduces SMAS, a Bayesian VAE-based AD score from structural MRI data, showing strong correlations with cognitive decline and brain atrophy markers, and outperforming existing measures in predicting AD.

Chemical inactivation of two non-enveloped viruses follows distinct molecular pathways

This study investigates how two non-enveloped viruses, HAdV5 and FCV, are inactivated by a chemical formulation, revealing distinct molecular pathways and synergistic effects.

Heterogeneous Slowdown of Dynamics in the Condensate of an Intrinsically Disordered Protein

This study uses MD simulations to show that self-crowding in FUS LCD condensates slows large-amplitude motions more than small-scale motions.

Radical differences between two FLIM microscopes affect interpretation of cell signaling dynamics

This study compares two FLIM microscopes and finds that differences in cAMP kinetics are due to phototoxicity from FluoroBrite medium, not the imaging technique itself.

A rewiring of the earliest immune events leading to T-cell mediated disease following intestinal infection in a PINK1 knock out mouse model of Parkinsons disease

This study identifies early immune dysregulation in PINK1 KO mice following intestinal infection, showing myeloid cell activation and T cell response as key factors in PD-like disease progression.

Membrane binding properties of the cytoskeletal protein bactofilin

This study identifies the membrane-targeting sequence of bactofilin BacA and reveals its molecular mechanism, conservation across bacterial species, and functional interplay with polymerization and client protein recruitment.

Legionella uses host Rab GTPases and BAP31 to create a unique ER niche

This study shows Legionella pneumophila transforms the host ER membrane into a distinct rER niche using Rab GTPases and BAP31.

Playback-aided surveys and acoustic monitoring in the detection of the Endangered Forest Owlet Athene blewitti

The paper evaluates playback-aided surveys and acoustic monitoring to detect the Forest Owlet in the Dang region, finding increased detections with new techniques but uncertainty about population trends.

Chloroquine attenuates hypoxia-mediated autophagy to curb thrombosis- an ex vivo and in vivo study

This paper shows chloroquine inhibits hypoxia-induced autophagy in platelets, reducing thrombosis in both ex vivo and in vivo models.

Comparative analysis of serological assays and sero-surveillance for SARS-CoV-2 exposure in US cattle

This study evaluates serological assays for SARS-CoV-2 in US cattle, finding no evidence of natural infection or transmission and highlighting issues with false positives in neutralization assays.

Genome-wide association study elucidates the genetic architecture of manganese tolerance in Brassica napus

This study identifies genetic loci and genes involved in manganese tolerance in canola using genome-wide association analysis and functional assays.

Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer

This paper develops an orally bioavailable PROTAC degrader of mSWI/SNF ATPases for prostate cancer and identifies resistance mechanisms through long-term treatment.

Structure of hepatitis B/D antiviral drug Bulevirtide bound to its receptor protein NTCP

The paper determines the cryo-EM structure of bulevirtide bound to NTCP, revealing its mechanism of inhibiting HBV/HDV entry and providing insights for drug development.

Leucaena and Acaia leaf litter negatively affect the survivorship of tadpoles of the South Asian frog Microhyla ornata

This study examines the impact of different leaf litter types on the survivorship of Microhyla ornata tadpoles, finding that Leucaena litter significantly reduces survival while Themeda litter supports higher survival.

G6PD deficiency mediated impairment of iNOS and lysosomal acidification affecting phagocytotic clearance in microglia in response to SARS-CoV-2

This study shows that G6PD deficiency in microglia impairs iNOS-mediated NO production and lysosomal acidification, leading to reduced phagocytosis of SARS-CoV-2 and increased COVID-19 severity.

Next-Gen Profiling of Tumor-resident Stem Cells using Machine learning

This paper introduces OSCORP, a machine learning method that identifies cancer stem cells with 99% accuracy using bulk RNAseq data, revealing CSC states and their clinical and transcriptomic signatures across 22 cancer types.

Nucleo-cytoplasmic environment modulates spatio-temporal p53 phase separation

This study shows that p53 phase separation and condensate formation are modulated by the nucleo-cytoplasmic environment and cancer-associated mutations affect condensate stability and DNA binding.

Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity

The paper shows that ionizing radiation enhances immunotherapy in pancreatic cancer by increasing tissue-resident NK cells that support CD8 T cell activity through cDC1-dependent mechanisms.

Calling site preference reduces masking interference of acoustic signals among sympatric bush frogs and facilitates coexistence

This study shows that sympatric frogs partition their acoustic space and call site height to reduce masking interference and facilitate coexistence.

Thermodynamic Forces from Protein and Water Govern Condensate Formation of an Intrinsically Disordered Protein Domain

This study uses molecular dynamics simulations to analyze the thermodynamic contributions of protein and water in FUS condensate formation, identifying solvation entropy and protein interaction enthalpy as key factors.

TMEM165 acts as a proton-activated Ca2+ importer in lysosomes

The paper identifies TMEM165 as a proton-activated Ca2+ importer in lysosomes, revealing a new mechanism for lysosomal Ca2+ refilling.

Cross-family small GTPase ubiquitination by the intracellular pathogen Legionella pneumophila

This study identifies how Legionella pneumophila modifies host ubiquitination during infection, revealing widespread monoubiquitination of small GTPases and the role of SidC/SdcA effectors.

ACKR3-arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding

This paper reports cryo-EM structures of ACKR3-arrestin2/3 complexes phosphorylated by GRK2 or GRK5, revealing how phosphorylation barcodes influence arrestin binding modes and receptor configuration.

p53 amyloid pathology with cancer grades and p53 mutations

The paper shows p53 amyloid load correlates with cancer grades and shows both mutant and wild-type p53 form amyloids in cancer tissues.

The Drosophila Tumour Suppressor Lgl and Vap33 activate the Hippo pathway by a dual mechanism, involving RtGEF/Git/Arf79F and inhibition of the V-ATPase.

This study shows Lgl activates the Hippo pathway via Vap33 through two mechanisms: interacting with RtGEF/Git/Arf79F and inhibiting V-ATPase activity.

Enantioselectivity in the Enzymatic Dehydration of Malate and Tartrate: Mirror Image Specificities of Structurally Similar Dehydratases

This study investigates the enantiomer-specificity of two structurally similar enzymes, FH and L-TTD, revealing evolutionary divergence in their substrate stereospecificity preferences.

The mature N termini of Plasmodium effector proteins confer specificity of export

This study shows that precise cleavage by signal peptidase to generate the mature N terminus is necessary for export of PEXEL proteins, while PM V cleavage is not required.

Connexin 43 mediated collective cell migration is independent of Golgi orientation

This study shows that Connexin 43 promotes collective cell migration by reducing Golgi reorientation, independent of directed secretory trafficking.

Chromatin condensation delays human mesenchymal stem cells senescence by safeguarding nuclear damages during long-term in vitro expansion

Quantifying the relationship between spreading depolarization and perivascular cerebrospinal fluid flow

This study develops a computational model linking spreading depolarization with perivascular cerebrospinal fluid flow, showing how PVS dimensions and SD wave properties affect CSF flow.