Conformational dynamics of -synuclein during the interaction with phospholipid nanodiscs by Millisecond Hydrogen Deuterium Exchange Mass Spectrometry
I. Oganesyan, C. Lento, A. Tandon, D. J. Wilson
This study uses HDX-MS to analyze conformational changes in α-synuclein when interacting with different lipid nanodiscs, identifying regions critical for amyloidogenic aggregation.
bioRxiv · Nov 16, 2020Biochemistry