Structural basis of promiscuous inhibition of Listeria virulence activator PrfA by oligopeptides
T. Hainzl, M. Scortti, C. Lindgren, C. Grundstrom, E. Krypotou, J. A. Vazquez-Boland, A. E. Sauer-Eriksson
The paper reveals how oligopeptides inhibit PrfA, a virulence activator in Listeria, by binding to its glutathione-binding tunnel and preventing its activation.
bioRxiv · May 24, 2024 · PreprintBiochemistry