HIV-1 accessory protein Vpr interacts with REAF and mitigates its associated antiviral 1 activity.
J. M. Gibbons, K. M. Marno, R. Pike, W.-y. J. Lee, C. E. Jones, B. W. Ogunkolade, C. Pardieu, A. Bryan, R. M. Fu, G. Warnes, P. A. Rowley, R. D. Sloan, A. McKnight
This paper shows that HIV-1 Vpr interacts with REAF, a macrophage-expressed antiviral factor, and promotes its degradation to enhance HIV replication.
bioRxiv · Oct 30, 2019Microbiology