The stability landscape of de novo TIM barrels explored by a modular design approach
S. Romero-Romero, M. Costas, D.-A. Silva, S. Kordes, E. Rojas-Ortega, Y. Guerra, C. Tapia, S. Shanmugaratnam, A. Rodriguez-Romero, D. Baker, B. Höcker, D. A. Fernandez-Velasco
This study designs a family of stable de novo TIM barrels with diverse thermodynamic properties and identifies epistatic effects influencing their stability.
bioRxiv · Sep 29, 2020Biochemistry