The acidic intrinsically disordered region of the inflammatory mediator HMGB1 mediates fuzzy interactions with chemokine CXCL12
M. V. Mantonico, F. De Leo, G. Quilici, L. Colley, F. De Marchis, M. Crippa, T. Schulte, C. Zucchelli, S. Ricagno, G. Giachin, m. ghitti, M. E. Bianchi, G. Musco
This study identifies the acidic intrinsically disordered region of HMGB1 as critical for forming a dynamic fuzzy heterocomplex with CXCL12, which enhances inflammatory signaling through CXCR4.
bioRxiv · Jun 6, 2023Biochemistry