Nutrient flux governs osteogenic fate commitment through the SLC3A1-cystine Axis
Yangshuai Gao, Qixuan Lin, Qing Xu, Shaokang Chen, Lu Jiang, Yun Hu, Cai Jp, Aaron Watkins James, Zhang Zh, Jiajia Xu
This study identifies SLC3A1-mediated cystine transport as a key regulator of osteogenic fate commitment and shows cystine supplementation promotes bone regeneration and mitigates osteoporosis.
bioRxiv · Jul 27, 2026 · PreprintCell Biology