IscR-mediated sensing of iron-sulfur cluster demand coordinates virulence gene expression in Yersinia pseudotuberculosis
Mané Ohanyan, George Imre Balazs, Karthik Hullahalli, Diana Fernandez Pacheco, Caia Lomeli, Katherine G. Dailey, Erin L. Mettert, Diana Hooker-Romero, Leah Schwiesow, Patricia J. Kiley, Matthew K. Waldor, Victoria Auerbuch
This paper shows that IscR, an iron-sulfur cluster sensor, regulates virulence gene expression in Yersinia pseudotuberculosis by responding to iron and oxygen levels, with mutations altering infection dynamics.
bioRxiv · Oct 16, 2025 · PreprintMicrobiology