Single-Cell RNA Sequencing and Inferred Protein Activity Analysis Reveal a Distinct Tumor Phenotype in Early-Onset Colorectal Cancer Patients
David A. Cohen, Aleksandar Obradović, Luka Jovanovic, Yosuke Mitani, Tianxia Li, Soobeom Lee, Dechokyab De, Casidhe-Nicole R. Bethancourt, Alice E. Shin, Karen J. Dunbar, Francesco Cambuli, Christopher J. Lengner, Ning Li, Caitlin Rogers, Jennifer Ho, , Joel T. Gabre
The paper compares early-onset and late-onset colorectal cancer using scRNA-seq and VIPER to identify distinct stromal and epithelial features in early-onset tumors.
bioRxiv · May 15, 2025 · PreprintCancer Biology