Cam-CAN

Functional connectome through the human life span

The paper analyzes functional and structural MRI data from 33,250 individuals to map lifespan changes in the functional connectome, identifying key developmental stages and differences in neurological disorders.

Behavioral and neuroimaging correlates of attentional biases to angry faces in individuals in remission from depression: a population-derived study

The paper investigates attentional biases to angry faces in individuals in remission from depression using functional MRI and drift diffusion modeling, finding persistent biases linked to brain activity in emotional regulation regions.

Neural contributions to reduced fluid intelligence across the adult lifespan

This paper investigates how age-related changes in frontoparietal brain activity mediate declines in fluid intelligence and identifies physical activity variety as a potential modifiable factor.

The "neural shift" of sleep quality and cognitive ageing: A resting-state MEG study of transient neural dynamics

This study uses resting-state MEG data to show that age-related changes in neural network dynamics are linked to sleep quality and cognitive decline.

Multimodal fusion analysis of functional, cerebrovascular and structural neuroimaging in healthy ageing subjects

This study uses linked ICA to analyze multimodal neuroimaging data from healthy ageing subjects, finding correlations between brain structure, vascular dynamics, and fluid intelligence.

Cerebral blood flow predicts multiple demand network activity and fluid intelligence across the lifespan

This study shows that baseline cerebral blood flow predicts multiple-demand network activity and fluid intelligence across the lifespan, with non-neuronal CBF effects confounding BOLD signals.

A morphometric double dissociation: cortical thickness is more related to aging; surface area is more related to cognition

This study shows cortical thickness is more linked to aging, while surface area is more linked to cognitive abilities, using brain imaging data from healthy adults.

Does Hemispheric Asymmetry Reduction in Older Adults (HAROLD) in motor cortex reflect compensation?

The paper investigates whether age-related hemispheric asymmetry reduction in motor cortex reflects compensation, finding no evidence for a compensatory mechanism.

The effects of age on resting-state BOLD signal variability is explained by cardiovascular and cerebrovascular factors

This study shows that age-related changes in resting-state BOLD signal variability are fully explained by cardiovascular and cerebrovascular factors, not neural activity or atrophy.

Genetic signatures of human brain structure: A comparison between GWAS and relatedness-based regression

This study compares GWAS and relatedness-based regression for identifying genetic variants associated with brain structure, finding they perform differently based on linkage disequilibrium levels.

Sensory attenuation is related to dopamine dose in Parkinson’s disease

This study investigates how dopamine levels in Parkinson’s disease patients affect sensory attenuation during voluntary movements, finding a negative correlation with motor severity and a positive correlation with dopamine dose.

Physical activity predicts population-level age-related differences in frontal white matter

The paper shows that physical activity preserves frontal white matter integrity and reduces age-related slowing in a population-based sample.

Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation and late-life activities

Age differentiation within grey matter, white matter and between memory and white matter in an adult lifespan cohort

The paper examines age-related changes in brain-cognition relationships across adulthood using structural equation modeling, finding neural differentiation but stable cognitive covariance.

How are age-related difference in sleep quality associated with health outcomes? An epidemiological investigation in a UK cohort of 2406 adults

This study investigates age-related differences in sleep quality and their associations with health outcomes in a UK cohort of 2406 adults, finding stronger links with mental health and u-shaped associations between sleep duration and mental health.

Symptoms of Depression in a Large Healthy Population Cohort are related to Subjective Memory Complaints and Memory Performance in Negative Contexts

This study examines how depressive symptoms affect memory complaints and performance in a large population cohort, finding a dissociation between subjective reports and objective measures, particularly in negative contexts.

A watershed model of individual differences in fluid intelligence

The paper develops a watershed model integrating white matter integrity, processing speed, and fluid intelligence in a lifespan cohort, showing a many-to-one mapping between these factors.