Cancer BiologyScientific ReportsPeer-reviewed
IGFs regulate cancer cell immune evasion in prostate cancer
Ashwin M. Nandakumar, Alessandro Barberis, Jin-Seon Kim…·Valentine M. Macaulay
This study shows IGF-1 suppresses immune-related pathways in prostate cancer cells, reducing antigen presentation and increasing PD-L1, which may explain poor immunotherapy response.