Logic-gating the HaloTag system with Conditional-Halo-ligator 'CHalo' reagents
Philipp Mauker, Carmen Zecha, Lucas Dessen-Weissenhorn, Luciano Román-Albasini, Joyce C. M. Meiring, Julia Ines Brandmeier, Daniela Beckmann, Jan P. Prohaska, Martin Reynders, Yi Louise Li, Kristina Mrug, Hannah von Schwerin, Nynke A. Vepřek, Julia F. Gaisbauer, Leif Dehmelt, , Oliver Thorn‐Seshold
The paper introduces CHalo reagents that conditionally ligate to HaloTag proteins, enabling light- or enzyme-triggered labeling, protein recruitment control, and enzyme activity recording.
bioRxiv · Sep 23, 2025 · PreprintCell Biology