CANCAN: high-resolution copy number and mutation heterogeneity analysis of DNA sequence data for clinical applications
Arne V. Pladsen, Daniel Vodák, Sen Zhao, Sigve Nakken, Daniel J. H. Nebdal, Tonje Gulbrandsen Lien, Britina Kjuul Danielsen, Caroline Wang, Wanja Kildal, Geir Olav Hjortland, Olav Engebråten, Eivind J. Hovig, Hege Giercksky Russnes, Ole Christian Lingjærde
The paper introduces CANCAN, a computational framework for analyzing copy number and mutation heterogeneity in DNA sequencing data, showing high concordance with existing methods and improved performance on targeted sequencing data.
bioRxiv · May 19, 2026 · PreprintBioinformatics