Mechanotransduction tuned by intermediate filaments promotes DNA repair in stiff environments
Cloe Dehours, Maelle Locatelli, Cassandra Lepetit, Amanda Smelser, Hyunsu Lee, Julia Holmes, Qianqian Song, Mohamed Gabber, Maelle Bertho, Sophie Lelievre, Keith Bonin, Martin Guthold, Pierre-Alexandre Vidi
The paper shows that rigid tissue environments enhance DNA repair efficiency and may contribute to cancer risk by promoting survival of damaged cells.
bioRxiv · Nov 2, 2026 · PreprintCell Biology