Author

Cassidy F Simas

University of Florida

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:yeast· 3 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Carl A. DenardiD· 3 shared Ethan W SlatoniD· 2 shared Julia T Besu· 2 shared Marian A PulgariD· 2 shared Sage E NelsoniD· 2 shared Samantha G. MartinuseniD· 2 shared Steven D. BruneriD· 2 shared Amit Kumar DuttaiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersSynthetic Biology

Carl A. DenardORCID

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3 papers

Recent·Most cited

High-throughput Activity Reprogramming of Proteases (HARP)

Samantha G. Martinusen, Ethan W Slaton, Seyednima Ajayebi, Marian A Pulgar, Cassidy F Simas, Sage E Nelson, Amit Kumar Dutta, Julia T Besu, Steven D. Bruner, Carl A. Denard

The paper introduces HARP, a yeast-based platform for discovering protease inhibitors, and demonstrates its ability to isolate low-nanomolar-range nanobodies against specific proteases.

ACS Chemical Biology · Sep 23, 2025Peer-reviewedSynthetic Biology

A scalable genetic tool for the functional analysis of the signal recognition particle.

Lawton F. Long, Shivani Biskunda, Ming Yang, George C. Wu, Cassidy F Simas, Steven D. Bruner, Carl A. Denard

This paper develops a yeast haploid model to study SRP54 mutations and their functional consequences, revealing dominant-negative phenotypes and growth defects associated with specific mutations.

bioRxiv · Jul 20, 2024 · PreprintSynthetic Biology

Modular and integrative activity reporters enhance biochemical studies in the yeast ER.

Samantha G. Martinusen, Ethan W Slaton, Sage E Nelson, Marian A Pulgar, Julia T Besu, Cassidy F Simas, Carl A. Denard

This paper expands the YESS system by creating integrative plasmids for modular and uniform activity reporting of PTM-enzymes in yeast.

Protein Engineering Design and Selection · Jan 1, 2024Peer-reviewedSynthetic Biology