Heterogeneity of HCMV-Specific CD8+ T Cells is Established Early in Infection, Clonally Encoded, and Stable Over Time
Samuel D. Klebanoff, Matthew F. Lawrance, Kimberly O’Brien, Megan E. Smithmyer, Cate Speak, Amy Susan Codd, Emily S. Ford, David M. Koelle, Jane Hoyt Buckner, Evan William Newell, Daniel Campbell
The paper tracks CMV-specific CD8+ T cells over time to show that clonal diversity and phenotypes are established early and remain stable during chronic infection.
bioRxiv · Oct 16, 2026 · PreprintImmunology