Author

Catherine Strand

National Hospital for Neurology and Neurosurgery

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 6

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1

Frequent Co-Authors

Janice L. HoltoniD· 5 shared Hilal Ahmed LashueliD· 4 shared Melek Firat AltayiD· 4 shared Adrià CasamitjanaiD· 2 shared Alessia AtzeniiD· 2 shared Anass ChikiiD· 2 shared Anne MicheliD· 2 shared Anne‐Laure Mahul‐MellieriD· 2 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersNeuroscience

Janice L. HoltonORCID

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6 papers

Recent·Most cited

Fast segmentation with the NextBrain histological atlas

Oula Puonti, Jackson C. Nolan, Robert Dicamillo, Yaël Balbastre, Adrià Casamitjana, Matteo Mancini, Eleanor Robinson, Loïc Peter, Roberto Annunziata, Juri Ibrahim M. Althonayan, Shauna Crampsie, Emily Blackburn, Benjamin Billot, Alessia Atzeni, Peter Schmidt, , Juan Eugenio Iglesias

The paper introduces a fast segmentation tool for brain MRI scans using a hybrid method, achieving comparable accuracy to a Bayesian approach but with significantly reduced runtime.

Imaging Neuroscience · Jan 1, 2026Peer-reviewedNeuroscience

Dissecting the differential role of C-terminal truncations in the regulation of aSyn pathology formation and the biogenesis of Lewy bodies

Anne‐Laure Mahul‐Mellier, Melek Firat Altay, Niran Maharjan, Nadine Ait‐Bouziad, Anass Chiki, Somanath Jagannath, Galina Limorenko, Salvatore Novello, Jonathan Ricci, Siv Vingill, Richard Wade‐Martins, Janice L. Holton, Catherine Strand, Caroline Haikal, Jiayi Li, , Hilal Ahmed Lashuel

This study investigates how C-terminal truncations of alpha-synuclein (aSyn) affect Lewy body (LB) formation and pathology in Parkinson's disease by analyzing their role in fibril processing and aggregation.

bioRxiv · Nov 29, 2024 · PreprintNeuroscience

A next-generation, histological atlas of the human brain and its application to automated brain MRI segmentation

Adrià Casamitjana, Matteo Mancini, Eleanor Robinson, Loïc Peter, Roberto Annunziata, Juri Ibrahim M. Althonayan, Shauna Crampsie, Emily Blackburn, Benjamin Billot, Alessia Atzeni, Oula Puonti, Yaël Balbastre, Peter Schmidt, James Hughes, Jean C. Augustinack, , Juan Eugenio Iglesias

The paper introduces NextBrain, a probabilistic histological atlas of the human brain, and presents a tool for automated MRI segmentation of anatomical regions.

bioRxiv · Feb 5, 2024 · PreprintNeuroscience

Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases

Melek Firat Altay, Senthil T. Kumar, Johannes Burtscher, Somanath Jagannath, Catherine Strand, Yasuo Miki, Laura Parkkinen, Janice L. Holton, Hilal Ahmed Lashuel

The paper develops and validates an expanded antibody panel to capture diverse alpha-synuclein conformations and modifications in Lewy body diseases.

npj Parkinson s Disease · Dec 7, 2023Peer-reviewedNeuroscience

Pathological relevance of post-translationally modified alpha-synuclein (pSer87, pSer129, nTyr39) in idiopathic Parkinson's disease and Multiple System Atrophy.

Berkiye Sonustun, Melek Firat Altay, Catherine Strand, Kirsten Ebanks, Geshanthi Hondhamuni, Thomas T. Warner, Hilal Ahmed Lashuel, Rina Bandopadhyay

The paper examines post-translational modifications of alpha-synuclein in Parkinson's disease and Multiple System Atrophy using immunohistochemistry to identify predominant PTMs in pathological aggregates.

Cells · Mar 6, 2022Peer-reviewedNeuroscience

The making of a Lewy body: the role of alpha-synuclein post-fibrillization modifications in regulating the formation and the maturation of pathological inclusions.

Anne‐Laure Mahul‐Mellier, Melek Firat Altay, Johannes Burtscher, Niran Maharjan, Nadine Ait‐Bouziad, Anass Chiki, Siv Vingill, Richard Wade‐Martins, Janice L. Holton, Catherine Strand, Caroline Haikal, Jiayi Li, Romain Hamelin, Marie Croisier, Graham William Knott, , Hilal Ahmed Lashuel

Calpain-1/2 cleavage of the alpha-synuclein C-terminus after fibril formation is reported to drive seeding, aggregation and the maturation of Lewy-body-like inclusions in primary neurons.

bioRxiv · Dec 19, 2018 · PreprintNeuroscience