Author

Charli Gruen

National Cancer Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:clustering· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Chi‐Ping DayiD· 3 shared Eva Pérez‐GuijarroiD· 3 shared Glenn T MerlinoiD· 3 shared Antonella SassanoiD· 2 shared Farid Rashidi MehrabadiiD· 2 shared Maxwell P. LeeiD· 2 shared S. Cenk ŞahinalpiD· 2 shared Salem MalikićiD· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

Chi‐Ping DayORCID

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3 papers

Recent·Most cited

Cancer BiologyCell SystemsPeer-reviewedDec 18, 2024

Stochastic modelling of single-cell gene expression adaptation reveals non-genomic contribution to evolution of tumor subclones

Mary G Hirsch, Soumitra Pal, Farid Rashidi Mehrabadi…·Teresa M. Przytycka

The paper models gene expression adaptation in tumor subclones using stochastic processes and finds non-genetic mechanisms drive subclonal evolution and treatment response.

22 citations

mousescRNA-seq

ImmunologybioRxivPreprintAug 26, 2024

IMMUNE AND MOLECULAR CORRELATES OF RESPONSE TO IMMUNOTHERAPY REVEALED BY BRAIN-METASTATIC MELANOMA MODELS.

Amélie Lopès, Eva Pérez‐Guijarro, Vishaka Gopalan…·Romina S. Goldszmid

This study develops mouse models of brain metastatic melanoma to identify immune and molecular factors influencing response to immunotherapy.

1 citation

mousebulk RNA-seq

BioinformaticsbioRxivPreprintMar 26, 2021

Profiles of expressed mutations in single cells reveal subclonal expansion patterns and therapeutic impact of intratumor heterogeneity

Farid Rashidi Mehrabadi, Kerrie L. Marie, Eva Pérez‐Guijarro…·S. Cenk Şahinalp

Trisicell infers subclonal expansion patterns and therapeutic impact of intratumor heterogeneity from scRNAseq data, revealing correlations between mutational composition and tumor aggressiveness.

15 citations

mousehuman