Massively Parallel Polyribosome Profiling Reveals Translation Defects of Human Disease-Relevant UTR Mutations
Jia-Ying Su, Wei-Ping Li, 김미진, Hung‐Lun Chiang, Yun-Lin Wang, Ang-Chu Huang, Yu-Tung Hsieh, Yi‐Hsuan Chiang, Yen-Ling Ko, Bing‐Jen Chiang, Cheng-Han Yang, Yen‐Tsung Huang, Chien‐Ling Lin
This study identifies UTR mutations that disrupt translation by altering polysome profiles and RNA structures, with a focus on uORF initiation sites and SRSF2 binding motifs.
bioRxiv · Apr 11, 2024 · PreprintGenetics