Elucidation and engineering of arabinofuranosyltransferase to enable total de novo biosynthesis of paris saponins in yeast
Haowen Wang, Yi Yang, Ziya Wu, Hongyun Zhao, Yinying Ba, Chi Zhang, Chenxing Sun, Z H Yu, Bowen Qiu, Liu X, Yating Hu, Xianan Zhang
This paper reports the first complete de novo biosynthesis of four bioactive Paris saponins in yeast by engineering sugar donor specificity and integrating biosynthetic modules.
ACS Sustainable Chemistry & Engineering · Jul 25, 2026Peer-reviewedSynthetic Biology