Epigenetically constrained astrocyte states underlie prefrontal cortex vulnerability in Down syndrome associated Alzheimer disease
Chuhanwen Sun, Raina W. Thomas, Cherie A Stringer, Kyriaki Galani, Li‐Lun Ho, Na Sun, Ashley Renfro, Sierra T. Wright, Rosalind Mott Firenze, Li‐Huei Tsai, Elizabeth Head, M Kellis, Jiekun Yang
The paper identifies a vulnerable astrocyte state in the prefrontal cortex of Down syndrome-associated Alzheimer's disease through integrated single-nucleus RNA-seq and ATAC-seq analysis.
bioRxiv · Apr 21, 2026 · PreprintBioinformatics