Reversible Antagonism of Dopamine D1 Receptor using a Photoswitchable Remotely Tethered Ligand
Belinda E. Hetzler, Prashant Donthamsetti, Robert M. Wolesensky, Cherise Stanley, Ehud Y. Isacoff, Dirk H. Trauner
The paper develops a photoswitchable antagonist for the dopamine D1 receptor to enable precise temporal and spatial control of receptor activity in the brain.
ACS Chemical Biology · Oct 16, 2025Peer-reviewedPharmacology & Toxicology